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Caroline Arout

Lecturer of Psychology

Dr. Caroline Arout is an Assistant Professor of Clinical Neurobiology (in Psychiatry) in the Division on Substance Use Disorders at the New York State Psychiatric Institute of Columbia University Irving Medical Center. There, Dr. Arout co-directs the Cannabis Research Laboratory, where her research focuses on the intersection of pain and substance use, emphasized by two main lines of human laboratory research: 1) the potential therapeutic utility of cannabinoids, in isolation or in combination with opioids, for pain in the context of abuse liability; 2) the study of medications to treat cannabis use disorder. Dr. Arout has authored over 30 publications in this area and has successfully obtained NIH and industry funding to study these important questions. She is also an active member of the College on Problems of Drug Dependence, serving on numerous committees and as a Board of Director At-Large.

More About Me

Dr. Arout maintains an active presence in education both in person and online; in addition to Purchase College, she also teaches for the City University of New York and Southern New Hampshire University. 

Representative Courses

Introduction to Psychology,
Research and Statistical Methods in Psychology,
Abnormal Psychology,
Physiological Psychology
Drugs and Behavior
Experimental Psychology,
Personal and Social Relationships
Neuropsychology

Publications

  • Jones, J., Martinez, S., Arout, C., Haney, M., Castillo, F., Manubay, J., Perez, F., Luba, R. R., & Comer, S. (2025). The effects of vaped cannabis on the severity of naloxone-precipitated opioid withdrawal. Experimental and Clinical Psychopharmacology,
  • Haney, M., Choo, T.H., Tiersten, A., Levin, F.R., Grassetti, A., DeSilva, N., Arout, C.A., & Martinez D. (2025). Oral cannabis for taxane-induced neuropathy: A pilot randomized placebo-controlled study. Cannabis and Cannabinoid Research,
  • Harris, H. M., Moore, C. F., Jenkins, B., Bedillion, M. F., Weerts, E. M., & Arout, C. A. (2025). Delta-9-tetrahydrocannabinol and cannabidiol for pain: Preclinical and clinical models, ePub ahead of print.
  • Bedillion, M. F., Moore, C. F., Weerts, E. M., Arout, C. A., Harris, H. H., & Haney, M. (2025). Pharmacology for cannabis use disorder: Preclinical and clinical models. In: Current Topics in Behavioral Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2025_598
  • Arout, C. , Harris, H. M, Mastropietro, K., Bozorgi, A., Fazilov, G., Tempero, J., Walker, M., & Haney, M. (2024). A preliminary pharmacokinetic comparison of delta-9-tetrahydrocannabinol and cannabidiol extract vs. oromucosal spray in health men and women. Cannabis and Cannabinoid Research, ePub ahead of print. PMID: 39648730; DOI: 10.1089/can.2023.0249.
  • Haney, M., Vallée, M., Fabre, S., Collins Reed, S., Zanese, M., Campistron, G., Arout, C. A., Foltin, R. W., Cooper, Z. D., Kearney-Ramos, T., Metna, M., Justinova, Z., Schindler, C., Hebert-Chatelain, E., Bellocchio, L., Cathala, A., Bari, A., Serrat, R., Finlay, D., B., Caraci, F., Redon, B., Martín-García, E., Busquets-Garcia, A., Matias, I., Levin, F. R., Felpin, F. X., Simon, N., Cota, D., Spampinato, U., Maldonado, R., Shaham, Y., Glass, M., Thomsen, L. L., Mengel, H., Marsicano, G., Monlezun, S., Revest, J-M., & Piazza, P. V. (2023). Signaling specific inhibition of the CB1 receptor for cannabis use disorder: Phase 1 and phase 2a randomized trials. Nature Medicine, ePub ahead of print. PMCID: PMC10287566.
  • Arout, C. A., Haney, M., Bedi, G., Herrmann, E., & Cooper, Z. D. (2022). The dose-dependent analgesic effects, abuse liability, safety and tolerability of oral cannabidiol in healthy volunteers. British Journal of Clinical Pharmacology, 88(1), 347-355. PMID: 34223660; DOI: 10.1111/bcp.14973.
  • Arout, C. A., Cooper, Z. D., Collins-Reed, S., Foltin, R. W., Comer, S. D., Levin, F. R., & Haney, M. (2021). 5HT-2c agonist lorcaserin decreases cannabis self-administration in daily cannabis smokers. Addiction Biology, PMCID: PMC8225547.
  • Arout, C. A., Petrakis, I. L., Ralevski, E., Acampora, G., Koretski, J., DeNegre, D., Newcomb, J., & Perrino, A. C. (2020). Thiopental does not produce hyperalgesia: A laboratory study using two experimental pain models. Pain Medicine, Epub ahead of print. PMCID: PMC8453625.
  • Arout, C. A. & Sofuoglu, M. (2019). Opioid Use Disorder. In F. Frankenburg (Ed.), Addictions: Incidence, Effects, Research, and Treatments. Santa Barbara, CA: ABC-CLIO.
  • Arout, C. A., Herrmann, E., & Haney, M. (2018). Human laboratory models of cannabis use disorder. In I. Montoya (Ed.), Cannabis Use Disorder, pp. 75-84. Chennai, India: Springer Nature.
  • Arout, C. A., Waters, A. J., Compton, P., MacLean, R. R., & Sofuoglu, M. (2018). Minocycline does not affect experimental pain or addiction-related outcomes in opioid-maintained patients. Psychopharmacology, 236(10), 2857-2866. PMID: 30564869. PMCID: PMC6581631.
  • Arout, C. A., Sofuoglu, M., & Rosenheck, R. A. (2017). Rates and correlates of specialized pain clinic utilization nationally in the Veterans Health Administration. Pain Medicine, 18(4), 702-710. PMID: 28082524; DOI: 10.1093/pm/pnw206.
  • Arout, C. A., Perrino Jr., A. C., Ralevski, E., Acampora, G., Koretski, J., Limoncelli, D., Newcomb, J., & Petrakis, I. (2016). Effect of intravenous ethanol on capsaicin-induced hyperalgesia in human subjects. Alcoholism: Clinical and Experimental Research, 40(7), 1425-1429. PMCID: 4930397.
  • Arout, C. A., Edens, E., Petrakis, I. L., & Sofuoglu, M. (2015). Targeting opioid-induced hyperalgesia in clinical treatment: Neurobiological considerations. CNS Drugs, 29, 465-486. PMID: 26142224; DOI: 10.1007/s40263-015-0255-x.
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