Originally from Rochester, NY, Chris Perfetti attended the Conservatory of Theatre Arts at the same time as Broadway actor Micah Stock and Andre Maybin Jr.
Perfetti appeared in Sons of the Prophet by playwright Stephen Karam, playing the role of Charlie, for which he received a Theatre World Award for Best Debut Performance in an Off-Broadway play. Starting in December 2012, Perfetti played Bomber in the revival of Picnic by William Inge. Perfetti appeared as Ariel in The Tempest at the Delacorte Theater in the summer of 2015.
His work extends beyond stage. As a screen actor, Perfetti starred in Submissions Only (2010), Next Caller (2012), and in the NBC series Crossbones (2014) as series regular Tim Fletch, and as the character Brady in the second season of the HBO show Looking (2015), and its subsequent series finale television film, Looking: The Movie (2016).
Perfetti continues to perform on stage and screen. He is currently (2018) performing in the Off-Broadway show The Low Road at the Public Theater in New York.